The TNFRSF10C Polyclonal Antibody (CAB1137) is a valuable tool for research involving TNFRSF10C, a cell surface receptor known to play a key role in regulating immune responses and cell apoptosis. This antibody, produced in rabbits, demonstrates high specificity and reactivity with human samples, making it suitable for various research applications such as Western blot analysis.TNFRSF10C, also known as TRAIL-R3, is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of programmed cell death.
Its role in apoptosis and immune signaling pathways makes it a target of interest in studies related to cancer biology, immunotherapy, and cell survival mechanisms. The TNFRSF10C Polyclonal Antibody enables the detection and analysis of TNFRSF10C protein expression in different cell types, contributing to a better understanding of its functions and potential therapeutic applications.
Product Name:
TNFRSF10C Rabbit Polyclonal Antibody
SKU:
CAB1137
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 150-238 of human TNFRSF10C (NP_003832.2).
Sequence:
VEEF GANA TVET PAAE ETMN TSPG TPAP AAEE TMNT SPGT PAPA AEET MTTS PGTP APAA EETM TTSP GTPA PAAE ETMT TSPG TPAS S
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.
Purification Method:
Affinity purification
Gene ID:
8794
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TNFRSF10C antibody (CAB1137) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180.
