The TNFRSF10A Polyclonal Antibody (CAB12540) is a valuable tool for researchers studying TNFRSF10A, a member of the tumor necrosis factor receptor superfamily known for its role in regulating cell death. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications, enabling the detection and analysis of TNFRSF10A protein in various cell types.TNFRSF10A, also known as DR4 or TRAIL-R1, is a receptor involved in the apoptotic pathway, making it a key player in controlling cell survival and death. Its dysregulation has been implicated in various diseases, including cancer, making it a promising target for therapeutic intervention.
By studying TNFRSF10A activity, researchers can gain insights into the molecular mechanisms underlying cell death and explore potential strategies for cancer treatment and other related conditions.With its specificity and reliability, the TNFRSF10A Polyclonal Antibody (CAB12540) is an essential tool for investigating the functions of TNFRSF10A in different biological contexts, providing valuable information for advancing our understanding of cell death regulation and its implications in disease.
Product Name:
TNFRSF10A Rabbit Polyclonal Antibody
SKU:
CAB12540
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 269-468 of human TNFRSF10A (NP_003835.3).
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.
Purification Method:
Affinity purification
Gene ID:
8797
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TNFRSF10A antibody (CAB12540) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
