The TNFR2 Polyclonal Antibody (CAB1095) is a powerful tool for researchers studying TNFR2, a receptor protein involved in the regulation of immune responses. This antibody, produced in rabbits, is specifically designed for use in experiments with human samples and has been validated for Western blot applications.TNFR2, also known as Tumor Necrosis Factor Receptor 2, plays a crucial role in modulating immune signaling pathways and promoting cell survival. By binding to the TNFR2 protein, this antibody enables researchers to detect and analyze TNFR2 expression in a variety of cell types, making it an essential tool for studies in immunology, cancer research, and autoimmune disorders.
The significance of TNFR2 in immune regulation makes it a promising target for therapeutic interventions in conditions such as cancer, inflammatory diseases, and autoimmune disorders. Understanding the functions of TNFR2 can provide valuable insights for the development of novel treatments that target immune responses and promote immune homeostasis.
Product Name:
TNFR2/TNFRSF1B Rabbit Polyclonal Antibody
SKU:
CAB1095
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 295-377 of human TNFR2/TNFRSF1B (NP_001057.1).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
48kDa
Observed MW:
75kDa
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.
Purification Method:
Affinity purification
Gene ID:
7133
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TNFR2/TNFRSF1B antibody (CAB1095) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
