The TNFAIP3 Rabbit Monoclonal Antibody (CAB19128) is a premium research tool for studying TNFAIP3, a key regulator of inflammatory signaling pathways in the immune system. This antibody, generated in rabbits, exhibits high specificity and sensitivity to TNFAIP3 protein in human samples, making it a reliable choice for Western blot analysis and immunohistochemistry studies.TNFAIP3, also known as A20, is a critical negative regulator of NF-κB signaling and pro-inflammatory cytokine production. Dysregulation of TNFAIP3 has been implicated in various autoimmune diseases, cancer, and inflammatory disorders. The TNFAIP3 Rabbit Monoclonal Antibody enables precise detection and quantification of TNFAIP3 expression levels in different cell types and tissues, providing valuable insights into the mechanisms of immune response modulation and inflammation regulation.
Researchers in immunology, oncology, and inflammatory disease fields will benefit from the use of this antibody in their experimental studies. By elucidating the roles of TNFAIP3 in disease pathogenesis, novel therapeutic targets and strategies for immune modulation may be identified, paving the way for enhanced treatment options and improved patient outcomes.
Product Name:
TNFAIP3 Rabbit Monoclonal Antibody
SKU:
CAB19128
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 450-550 of human TNFAIP3 (P21580).
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
7128
Clone Number:
ARC0355
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using TNFAIP3 Rabbit mAb (CAB19128) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
