The TNFAIP3 Polyclonal Antibody (CAB13637) is a valuable tool for researchers studying TNFAIP3, a key regulator of inflammation and immune responses. This antibody, developed in rabbits, has high specificity for human samples and has been validated for use in Western blot applications.TNFAIP3, also known as A20, is involved in the negative regulation of NF-κB signaling and plays a crucial role in maintaining immune homeostasis. Dysregulation of TNFAIP3 has been linked to various autoimmune diseases, inflammatory conditions, and cancer.
By targeting TNFAIP3, researchers can gain insights into the underlying mechanisms of these diseases and potentially develop new therapies aimed at modulating immune responses. The TNFAIP3 Polyclonal Antibody is an essential tool for studies in immunology, oncology, and inflammatory diseases, providing reliable detection and analysis of TNFAIP3 protein levels in different cell types.
Product Name:
TNFAIP3 Rabbit Polyclonal Antibody
SKU:
CAB13637
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human TNFAIP3 (NP_006281.1).
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
7128
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunofluorescence analysis of U2OS cells using TNFAIP3 antibody (CAB13637). Blue: DAPI for nuclear staining.
