The TNF Receptor II Rabbit Monoclonal Antibody (CAB19127) is a cutting-edge research tool designed for the study of TNF receptor II, a key player in the regulation of immune responses and inflammation. This antibody, developed using rabbit monoclonal technology, demonstrates high specificity and sensitivity in detecting TNF receptor II in human samples.TNF receptor II, also known as TNFRSF1B, is an important mediator of the TNF signaling pathway, which plays a central role in the immune system's response to infections and inflammatory diseases. By targeting TNF receptor II, researchers can gain insights into the mechanisms underlying various diseases, including autoimmune disorders, cancer, and chronic inflammatory conditions.
This antibody is thoroughly validated for use in Western blot applications, enabling precise and reliable detection of TNF receptor II in different cell types and experimental settings. Its superior performance makes it an invaluable tool for researchers investigating the complex interplay between TNF receptor II and immune function, paving the way for the development of novel therapeutic strategies targeting this important pathway.
Product Name:
TNFR2/TNFRSF1B Rabbit Monoclonal Antibody
SKU:
CAB19127
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 362-461 of human TNFR2/TNFRSF1B (P20333).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
48kDa
Observed MW:
68kDa
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.
Purification Method:
Affinity purification
Gene ID:
7133
Clone Number:
ARC0397
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TNFR2/TNFRSF1B antibody (CAB19127) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
