TNF-α Polyclonal Antibody (CAB21769)
- SKU:
- CAB21769
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
Product Name: | TNF-α Polyclonal Antibody |
SKU: | CAB21769 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 80-235 of mouse TNF-α (NP_038721.1). |
Sequence: | LRSS SQNS SDKP VAHV VANH QVEE QLEW LSQR ANAL LANG MDLK DNQL VVPA DGLY LVYS QVLF KGQG CPDY VLLT HTVS RFAI SYQE KVNL LSAV KSPC PKDT PEGA ELKP WYEP IYLG GVFQ LEKG DQLS AEVN LPKY LDFA ESGQ VYFG VIAL |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | DIF; Tnfa; TNF-a; TNFSF2; Tnlg1f; Tnfsf1a; TNFalpha; TNF-alpha; TNF-α |
Conjugate: | Unconjugated |
Cellular Localization: | cell surface, cytoplasm, external side of plasma membrane, extracellular region, extracellular space, phagocytic cup, plasma membrane, recycling endosome |
Calculated MW: | 26kDa |
Observed MW: | Refer to figures |
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. Members of this family are classified based on primary sequence, function, and structure. This protein is synthesized as a type-II transmembrane protein and is reported to be cleaved into products that exert distinct biological functions. It plays an important role in the innate immune response as well as regulating homeostasis but is also implicated in diseases of chronic inflammation. In mouse deficiency of this gene is associated with defects in response to bacterial infection, with defects in forming organized follicular dendritic cell networks and germinal centers, and with a lack of primary B cell follicles. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 21926 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |