TNF Antibody (PACO32616)
- SKU:
- PACO32616
- Product Type:
- Antibody
- Reactivity:
- Bovine
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
TNF Antibody (PACO32616)
The TNF Polyclonal Antibody (PAC032616) is a vital tool for researchers studying tumor necrosis factor (TNF), a key cytokine involved in inflammation, immune response, and apoptosis. This antibody, generated in rabbits, exhibits high specificity and sensitivity for TNF detection in human samples, making it a valuable asset for various research applications such as Western blotting.TNF plays a crucial role in the regulation of immune responses and the development of inflammatory diseases. Dysregulation of TNF signaling has been linked to conditions such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis.
By targeting TNF with this antibody, researchers can gain insights into the mechanisms underlying these diseases and explore potential therapeutic interventions.With its ability to specifically detect TNF and facilitate its analysis in different cell types, the TNF Polyclonal Antibody is an essential tool for advancing research in immunology, inflammation, and disease pathology. Researchers can rely on this antibody to support their studies and contribute to a better understanding of TNF biology and its implications in various disease states.
| Antibody Name: | TNF Antibody (PACO32616) |
| Antibody SKU: | PACO32616 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Bovine |
| Immunogen: | Recombinant Bovine Tumor necrosis factor protein (78-234AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: TNF antibody at 2µg/ml Lane 1: 293T whole cell lysate Lane 2: EC109 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/15000 dilution Predicted band size: 26 kDa Observed band size: 60 kDa . |
| Synonyms: | Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form], TNF, TNFA TNFSF2 |
| UniProt Protein Function: | Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q06599 |
| NCBI GenInfo Identifier: | 150421693 |
| NCBI Gene ID: | 280943 |
| NCBI Accession: | Q06599.2 |
| UniProt Secondary Accession: | Q06599,O18779, Q27978, A4IFT5, A9QWR7 |
| UniProt Related Accession: | Q06599 |
| Molecular Weight: | 25,439 Da |
| NCBI Full Name: | Tumor necrosis factor |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | TNFÂ Â |
| NCBI Official Synonym Symbols: | TNFa; TNF-a; TNF-alpha  |
| NCBI Protein Information: | tumor necrosis factor |
| UniProt Protein Name: | Tumor necrosis factor |
| UniProt Synonym Protein Names: | Cachectin; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a |
| Protein Family: | |
| UniProt Gene Name: | TNFÂ Â |
| UniProt Entry Name: | TNFA_BOVIN |
| ELISA Kits |
| Bovine TNF-alpha (Tumor necrosis factor alpha) ELISA Kit (BOFI00144) |
| Bovine Tumor necrosis factor (TNF) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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