TNF Antibody (PACO30690)
- SKU:
- PACO30690
- Product Type:
- Antibody
- Reactivity:
- Sheep
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
TNF Antibody (PACO30690)
The TNF Polyclonal Antibody (PACO30690) is a valuable tool for researchers studying tumor necrosis factor (TNF), a key cytokine involved in various inflammatory processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to TNF, researchers can accurately detect and analyze TNF expression in a variety of cell types, making it an essential component for studies in immunology, inflammation, and cancer research.
TNF plays a pivotal role in the regulation of immune responses and the development of inflammatory conditions. Abnormal regulation of TNF has been implicated in a variety of diseases, including autoimmune disorders, chronic inflammatory conditions, and cancer. The TNF Polyclonal Antibody offers researchers a precise tool for investigating TNF expression and function, providing valuable insights into the development of targeted therapies for TNF-related diseases.
| Antibody Name: | TNF Antibody (PACO30690) |
| Antibody SKU: | PACO30690 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Sheep |
| Immunogen: | Recombinant Sheep Tumor necrosis factor protein (78-234AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: Tumor necrosis factor antibody at dilution of 1: 1000 Lane 1: Tumor necrosis factor protein at 0.05µg Lane 2: Tumor necrosis factor protein at 0.5µg Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 26 kDa Observed band size: 26 kDa . |
| Background: | Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells |
| Synonyms: | Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form], TNF, TNFA TNFSF2 |
| UniProt Protein Function: | Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P23383 |
| NCBI GenInfo Identifier: | 67845989 |
| NCBI Gene ID: | 443540 |
| NCBI Accession: | NP_001020031.1 |
| UniProt Secondary Accession: | P23383 |
| UniProt Related Accession: | P23383 |
| Molecular Weight: | |
| NCBI Full Name: | tumor necrosis factor |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | TNFÂ Â |
| NCBI Official Synonym Symbols: | TNF-alpha  |
| NCBI Protein Information: | tumor necrosis factor; TNF-a; cachectin; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor ligand superfamily member 2 |
| UniProt Protein Name: | Tumor necrosis factor |
| UniProt Synonym Protein Names: | Cachectin; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a |
| Protein Family: | Tumor necrosis factor |
| UniProt Gene Name: | TNFÂ Â |
| UniProt Entry Name: | TNFA_SHEEP |
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