TNF-α Rabbit Polyclonal Antibody (CAB11534)
- SKU:
- CAB11534
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | TNF-α Rabbit Polyclonal Antibody |
SKU: | CAB11534 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 134-233 of human TNF-α (NP_000585.2). |
Sequence: | IYSQ VLFK GQGC PSTH VLLT HTIS RIAV SYQT KVNL LSAI KSPC QRET PEGA EAKP WYEP IYLG GVFQ LEKG DRLS AEIN RPDY LDFA ESGQ VYFG IIAL |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:500 - 1:1000 IF/ICC,1:50 - 1:100 |
Synonyms: | DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha; TNF-α |
Positive Sample: | THP-1 |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Membrane, Secreted, Single-pass type II membrane protein, Single-pass type II membrane protein. |
Calculated MW: | 26kDa |
Observed MW: | 18kDa/25kDa |
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, psoriasis, rheumatoid arthritis ankylosing spondylitis, tuberculosis, autosomal dominant polycystic kidney disease, and cancer. Mutations in this gene affect susceptibility to cerebral malaria, septic shock, and Alzheimer disease. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
Purification Method: | Affinity purification |
Gene ID: | 7124 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |