TNF-α Rabbit Polyclonal Antibody (CAB0277)
- SKU:
- CAB0277
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | TNF-α Rabbit Polyclonal Antibody |
SKU: | CAB0277 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 77-233 of human TNF (NP_000585.2). |
Sequence: | VRSS SRTP SDKP VAHV VANP QAEG QLQW LNRR ANAL LANG VELR DNQL VVPS EGLY LIYS QVLF KGQG CPST HVLL THTI SRIA VSYQ TKVN LLSA IKSP CQRE TPEG AEAK PWYE PIYL GGVF QLEK GDRL SAEI NRPD YLDF AESG QVYF GIIA L |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha; TNF-α |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Membrane, Secreted, Single-pass type II membrane protein, Single-pass type II membrane protein. |
Calculated MW: | 26kDa |
Observed MW: | Refer to figures |
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, psoriasis, rheumatoid arthritis ankylosing spondylitis, tuberculosis, autosomal dominant polycystic kidney disease, and cancer. Mutations in this gene affect susceptibility to cerebral malaria, septic shock, and Alzheimer disease. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
Purification Method: | Affinity purification |
Gene ID: | 7124 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |