The TMX2 Polyclonal Antibody (CAB17148) is a valuable tool for researchers studying the TMX2 protein, a key player in protein folding and disulfide bond formation in the endoplasmic reticulum. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.TMX2 is involved in the maintenance of cellular redox homeostasis and proper protein folding, making it essential for cellular function and viability. Dysregulation of TMX2 has been implicated in various diseases, including neurodegenerative disorders and cancer.
By targeting TMX2 with this antibody, researchers can detect and analyze the protein in different cell types, enabling a deeper understanding of its role in disease pathogenesis.The TMX2 Polyclonal Antibody is a powerful tool for investigating the function of TMX2 in physiological and pathological conditions. Its use in research may lead to the development of novel therapeutic strategies for diseases associated with protein misfolding and oxidative stress.
Product Name:
TMX2 Rabbit Polyclonal Antibody
SKU:
CAB17148
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 128-296 of human TMX2 (NP_057043.1).
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and a C-terminal ER-retention sequence. This protein is enriched on the mitochondria-associated-membrane of the ER via palmitoylation of two of its cytosolically exposed cysteines.
Purification Method:
Affinity purification
Gene ID:
51075
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TMX2 pAb (CAB17148) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
