The TMX1 Polyclonal Antibody (CAB17219) is a valuable tool for researchers studying the TMX1 protein, an essential component in protein folding and quality control within the endoplasmic reticulum. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the TMX1 protein, researchers can easily detect and analyze TMX1 expression in a variety of cell types, making it an ideal choice for studies related to protein folding, quality control, and endoplasmic reticulum stress.TMX1 is a key player in maintaining protein homeostasis and preventing the accumulation of misfolded proteins, which can lead to cellular dysfunction and disease.
Dysregulation of TMX1 has been linked to conditions such as neurodegenerative diseases, cancer, and cardiovascular disorders, highlighting its importance in maintaining cellular health. By studying TMX1 activity and expression levels, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets for intervention.Overall, the TMX1 Polyclonal Antibody (CAB17219) offers researchers a reliable tool for investigating the role of TMX1 in protein quality control and disease pathogenesis. Its high specificity and reactivity make it a valuable asset for studies in molecular biology, cell biology, and disease research.
Product Name:
TMX1 Rabbit Polyclonal Antibody
SKU:
CAB17219
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 210-280 of human TMX1 (NP_110382.3).
Endoplasmic reticulum membrane, Membrane, Single-pass type I membrane protein.
Calculated MW:
32kDa
Observed MW:
35kDa
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and one transmembrane domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The mature membrane-bound protein can both oxidize and reduce disulfide bonds and acts selectively on membrane-associated polypeptides.
Purification Method:
Affinity purification
Gene ID:
81542
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TMX1 Rabbit pAb (CAB17219) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
