The TMX1 Polyclonal Antibody (CAB14936) is a valuable tool for researchers studying TMX1, a protein involved in protein folding and ER stress response. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the TMX1 protein, this antibody enables accurate detection and analysis, making it ideal for studies in cell biology and protein folding mechanisms.TMX1 is known to play a crucial role in maintaining protein homeostasis and proper protein folding within the endoplasmic reticulum.
Dysregulation of TMX1 has been implicated in diseases such as neurodegenerative disorders and cancer, making it a promising target for therapeutic interventions. By understanding the function and regulation of TMX1, researchers can uncover novel insights into disease mechanisms and develop new strategies for treatment.
Product Name:
TMX1 Rabbit Polyclonal Antibody
SKU:
CAB14936
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 210-280 of human TMX1 (NP_110382.3).
Endoplasmic reticulum membrane, Membrane, Single-pass type I membrane protein.
Calculated MW:
32kDa
Observed MW:
35kDa
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and one transmembrane domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The mature membrane-bound protein can both oxidize and reduce disulfide bonds and acts selectively on membrane-associated polypeptides.
Purification Method:
Affinity purification
Gene ID:
81542
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TMX1 Rabbit pAb (CAB14936) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
