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TMPRSS3 Antibody (PACO20719)

SKU:
PACO20719
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339

Description

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TMPRSS3 Antibody (PACO20719)

The TMPRSS3 Polyclonal Antibody (PACO20719) is a valuable tool for researchers studying TMPRSS3, a transmembrane serine protease that plays a critical role in various biological processes. This antibody, generated in rabbits, exhibits high specificity and reactivity towards human samples, making it ideal for use in Western blot applications. By binding to the TMPRSS3 protein, this antibody enables precise detection and analysis in a variety of cell types, allowing for detailed investigations in fields such as molecular biology and cancer research.TMPRSS3 is known for its involvement in processes such as cell signaling, protein processing, and viral entry, highlighting its importance in normal physiological functions as well as in disease pathology.

Researchers can utilize this antibody to explore the functions and mechanisms of TMPRSS3, shedding light on its potential role in diseases such as cancer, viral infections, and genetic disorders. By gaining a deeper understanding of TMPRSS3, researchers can pave the way for the development of innovative therapeutic strategies targeting this protein for improved disease management and treatment outcomes.

Antibody Name:TMPRSS3 Antibody (PACO20719)
Antibody SKU:PACO20719
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:Human, Mouse
Immunogen:Synthetic peptide of human TMPRSS3
Form:Liquid
Storage Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:Antigen affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20719(TMPRSS3 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described.
Synonyms:transmembrane protease, serine 3
UniProt Protein Function:TMPRSS3: Probable serine protease that play a role in hearing. Acts as a permissive factor for cochlear hair cells survival and activation at the onset of hearing and is required for saccular hair cell survival. Activates ENaC (in vitro). Defects in TMPRSS3 are the cause of deafness autosomal recessive type 8 (DFNB8). DFNA8 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Defects in TMPRSS3 are the cause of deafness autosomal recessive type 10 (DFNB10). Belongs to the peptidase S1 family. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Protease; Membrane protein, integral; Endoplasmic reticulum; EC 3.4.21.-

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane

Molecular Function:sodium channel regulator activity

Biological Process: cellular sodium ion homeostasis

Disease: Deafness, Autosomal Recessive 8

NCBI Summary:This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]
UniProt Code:P57727
NCBI GenInfo Identifier:13124582
NCBI Gene ID:64699
NCBI Accession:P57727.2
UniProt Secondary Accession:P57727,Q5USC7, Q6ZMC3, D3DSJ6,
UniProt Related Accession:P57727
Molecular Weight:58,324 Da
NCBI Full Name:Transmembrane protease serine 3
NCBI Synonym Full Names:transmembrane protease, serine 3
NCBI Official Symbol:TMPRSS3  
NCBI Official Synonym Symbols:DFNB8; DFNB10; ECHOS1; TADG12  
NCBI Protein Information:transmembrane protease serine 3
UniProt Protein Name:Transmembrane protease serine 3
UniProt Synonym Protein Names:Serine protease TADG-12; Tumor-associated differentially-expressed gene 12 protein
Protein Family:Transmembrane protease serine
UniProt Gene Name:TMPRSS3  
UniProt Entry Name:TMPS3_HUMAN
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