The TMPRSS2 Rabbit Monoclonal Antibody (CAB9126) is specifically designed for research involving TMPRSS2, a type II transmembrane serine protease that plays a critical role in viral infection, particularly with coronaviruses such as SARS-CoV-2. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications including Western blot and immunohistochemistry.TMPRSS2 is known to cleave viral spike proteins, facilitating viral entry into host cells. Understanding the expression and activity of TMPRSS2 is crucial for studying viral pathogenesis and developing therapeutics targeting viral entry processes.
The TMPRSS2 Rabbit Monoclonal Antibody enables researchers to detect and analyze TMPRSS2 protein levels in different cell types, providing valuable insights into virus-host interactions and potential therapeutic strategies.With its high specificity and sensitivity, the TMPRSS2 Rabbit Monoclonal Antibody is a valuable tool for studies in virology, infectious diseases, and respiratory illnesses. By targeting TMPRSS2, researchers can uncover new avenues for combating viral infections, including the development of antiviral drugs and vaccines.
Product Name:
TMPRSS2 Rabbit Monoclonal Antibody
SKU:
CAB9126
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TMPRSS2 (O15393).
Cell membrane, Secreted, Single-pass type II membrane protein.
Calculated MW:
54kDa
Observed MW:
52kDa
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. This protein also facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. Viruses found to use this protein for cell entry include Influenza virus and the human coronaviruses HCoV-229E, MERS-CoV, SARS-CoV and SARS-CoV-2 (COVID-19 virus). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
7113
Clone Number:
ARC1439
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using TMPRSS2 Rabbit mAb (CAB9126) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 3min.
