TMPRSS2 Rabbit Polyclonal Antibody (CAB1979)
- SKU:
- CAB1979
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | TMPRSS2 Rabbit Polyclonal Antibody |
SKU: | CAB1979 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TMPRSS2 (NP_005647.3). |
Sequence: | MALN SGSP PAIG PYYE NHGY QPEN PYPA QPTV VPTV YEVH PAQY YPSP VPQY APRV LTQA SNPV VCTQ PKSP SGTV CTSK TKKA LCIT LTLG TFLV GAAL |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | PRSS10; TMPRSS2 |
Positive Sample: | Mouse kidney,Mouse stomach,Rat large intestine,Rat lung,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Secreted, Single-pass type II membrane protein. |
Calculated MW: | 54kDa |
Observed MW: | 70kDa/32kDa |
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. This protein also facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. Viruses found to use this protein for cell entry include Influenza virus and the human coronaviruses HCoV-229E, MERS-CoV, SARS-CoV and SARS-CoV-2 (COVID-19 virus). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 7113 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |