The TMPRSS2 Polyclonal Antibody (CAB1979) is a valuable tool for researchers studying TMPRSS2, a serine protease involved in various cellular processes, including viral entry and activation of protease-activated receptors. This antibody, derived from rabbit immunization, is highly specific to human samples and has been validated for use in Western blot applications.TMPRSS2 is known for its role in viral infections, particularly in facilitating the entry of certain viruses into host cells. By targeting the TMPRSS2 protein, researchers can investigate its involvement in viral pathogenesis and explore potential therapeutic interventions for viral diseases.
Additionally, TMPRSS2 has been implicated in cancer progression and metastasis, making it a promising target for oncology research. Understanding the function and regulation of TMPRSS2 can provide valuable insights into cancer biology and may lead to the development of novel treatment strategies.Overall, the TMPRSS2 Polyclonal Antibody is a versatile tool for researchers interested in exploring the diverse roles of TMPRSS2 in health and disease, providing essential support for studies in virology, oncology, and beyond.
Product Name:
TMPRSS2 Rabbit Polyclonal Antibody
SKU:
CAB1979
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TMPRSS2 (NP_005647.3).
Mouse kidney,Mouse stomach,Rat large intestine,Rat lung,Rat kidney
Conjugate:
Unconjugated
Cellular Localization:
Cell membrane, Secreted, Single-pass type II membrane protein.
Calculated MW:
54kDa
Observed MW:
70kDa/32kDa
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. This protein also facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. Viruses found to use this protein for cell entry include Influenza virus and the human coronaviruses HCoV-229E, MERS-CoV, SARS-CoV and SARS-CoV-2 (COVID-19 virus). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
7113
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using TMPRSS2 Rabbit pAb (CAB1979) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
