The TMPRSS15 Polyclonal Antibody (PAC051878) is a valuable tool for researchers studying TMPRSS15, a transmembrane serine protease involved in various biological processes. This antibody, generated in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications. By binding to the TMPRSS15 protein, this antibody allows for precise detection and analysis in different cell types, making it an ideal choice for studies in molecular biology and disease pathology.TMPRSS15, also known as enterokinase-2, plays a crucial role in protein processing and activation, particularly in the digestive system.
Its involvement in the proteolytic cleavage of other proteins underscores its significance in regulating physiological functions. Research on TMPRSS15 is essential for understanding its contribution to digestive disorders, such as inflammatory bowel disease and pancreatic cancer, and for exploring its potential as a therapeutic target in these conditions. By investigating the mechanisms and functions of TMPRSS15, scientists can gain insights that may lead to the development of innovative treatments for gastrointestinal diseases.
Antibody Name:
Tmprss15 Antibody (PACO51878)
Antibody SKU:
PACO51878
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:
Mouse, Human, Rat
Immunogen:
Recombinant Mouse Enteropeptidase protein (830-1069AA)
Western Blot. Positive WB detected in: HepG2 whole cell lysate, Rat liver tissue. All lanes: Tmprss15 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 119 kDa. Observed band size: 119 kDa..
Background:
Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases (By similarity).
PRSS7: Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases. Defects in TMPRSS15 are a cause of enterokinase deficiency (ENTKD); a life-threatening intestinal malabsorption disorder characterized by diarrhea and failure to thrive. Belongs to the peptidase S1 family.Protein type: Protease; EC 3.4.21.9; Membrane protein, integralCellular Component: integral to membrane; membraneMolecular Function: hydrolase activity; peptidase activity; scavenger receptor activity; serine-type endopeptidase activity; serine-type peptidase activityBiological Process: proteolysis
