The TMPRSS11D Polyclonal Antibody (CAB10132) is specifically designed for research involving TMPRSS11D, a transmembrane serine protease implicated in various physiological processes. The antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. It efficiently binds to the TMPRSS11D protein, enabling accurate detection and analysis in a variety of cell types, making it an excellent tool for studies in molecular biology and disease research.
TMPRSS11D, also known as matriptase-2, is a key player in processes such as epithelial barrier function, iron homeostasis, and regulation of inflammatory responses. Its involvement in these pathways makes it a promising target for research into conditions like liver disease, anemia, and inflammatory disorders. Understanding the function of TMPRSS11D is essential for developing potential therapies that target its activity in these disease contexts.
Product Name:
TMPRSS11D Rabbit Polyclonal Antibody
SKU:
CAB10132
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 42-292 of human TMPRSS11D (NP_004253.1).
Cell membrane, Secreted, Single-pass type II membrane protein.
Calculated MW:
46kDa
Observed MW:
46kDa
This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. This protein facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins.
Purification Method:
Affinity purification
Gene ID:
9407
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TMPRSS11D antibody (CAB10132) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
