The TMPRSS11B Polyclonal Antibody (PACO17285) is a valuable tool for researchers studying TMPRSS11B, a type II transmembrane serine protease involved in various physiological processes, including cell signaling and tissue remodeling. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the TMPRSS11B protein, this antibody enables precise detection and analysis in a variety of cell types, making it well-suited for investigations in fields such as molecular biology and cell signaling.
TMPRSS11B, also known as matriptase-2, plays a crucial role in regulating proteolytic activity and maintaining tissue homeostasis. Its involvement in processes such as cell proliferation and tissue repair highlights its relevance in research areas like cancer biology, developmental biology, and tissue regeneration. Understanding the mechanisms of TMPRSS11B activity is essential for uncovering its potential as a therapeutic target in diseases related to dysregulated protease activity.
Antibody Name:
TMPRSS11B Antibody (PACO17285)
Antibody SKU:
PACO17285
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:10-1:50
Species Reactivity:
Human
Immunogen:
Fusion protein of human TMPRSS11B
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO17285(TMPRSS11B Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
TMPRSS11B (transmembrane protease serine 11B), also known as airway trypsin-like protease 5, is a 416 amino acid, single-pass type II membrane protein that belongs to the peptidase S1 family and contains one peptidase S1 domain and one SEA domain. The gene that encodes TMPRSS11B consists of over 19,000 bases and maps to human chromosome 4q13.2. Chromosome 4 represents approximately 6% of the human genome and contains nearly 900 genes. Notably, the Huntingtin gene, which is found to encode an expanded glutamine tract in cases of Huntington's disease, is encoded by a gene that maps to chromosome 4. FGFR-3 is also encoded by a gene located on chromosome 4 and has been associated with thanatophoric dwarfism, achondroplasia, Muenke syndrome and bladder cancer. Chromosome 4 is also tied to Ellis-van Creveld syndrome, methylmalonic acid, mia and polycystic kidney disease.
Synonyms:
transmembrane protease, serine 11B
UniProt Protein Function:
TMPRSS11B: Probable serine protease. Belongs to the peptidase S1 family.Protein type: EC 3.4.21.-; Membrane protein, integral; ProteaseChromosomal Location of Human Ortholog: 4q13.2Cellular Component: plasma membraneMolecular Function: serine-type peptidase activity
