The TMIGD2 Polyclonal Antibody (PAC050894) is a valuable tool for research involving TMIGD2, a transmembrane and immunoglobulin domain-containing protein with potential significance in immune regulation. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. It binds to the TMIGD2 protein, allowing for accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in immunology and cancer research.TMIGD2 is a novel protein that may play a role in immune function, although its exact mechanisms are still being elucidated.
Research suggests that TMIGD2 may be involved in immune cell activation and modulation of immune responses, highlighting its potential as a target for therapeutic interventions in diseases such as cancer, autoimmune disorders, and inflammatory conditions. Understanding the function of TMIGD2 could provide valuable insights into the development of treatments that target immune dysregulation in these contexts.
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO50894 at dilution of 1:100.
Immunofluorescent analysis of PC-3 cells using PACO50894 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
Synonyms:
Transmembrane and immunoglobulin domain-containing protein 2 (CD28 homolog) (Immunoglobulin and proline-rich receptor 1) (IGPR-1), TMIGD2, CD28H IGPR1
UniProt Protein Function:
IGPR-1: Plays a role in cell-cell interaction, cell migration, and angiogenesis. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 19p13.3Cellular Component: integral to membrane; plasma membraneMolecular Function: protein binding; coreceptor activityBiological Process: positive regulation of cytokine production; T cell costimulation; signal transduction; positive regulation of activated T cell proliferation
