The TMEM88 Polyclonal Antibody (PAC059920) is a valuable tool for researchers studying TMEM88, a transmembrane protein involved in various cellular processes. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the TMEM88 protein, this antibody allows for the detection and analysis of TMEM88 levels in different cell types, making it suitable for studies in cell biology, signal transduction, and developmental biology.
TMEM88 is known to play a role in cell proliferation, migration, and differentiation, making it a promising target for research in cancer biology, developmental biology, and neurobiology. Understanding the function and regulation of TMEM88 can provide insights into its potential implications in disease mechanisms and therapeutic strategies. By using the TMEM88 Polyclonal Antibody, researchers can uncover new information about the role of TMEM88 in various physiological and pathological processes.
Antibody Name:
TMEM88 Antibody (PACO59920)
Antibody SKU:
PACO59920
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Transmembrane protein 88 protein (109-159AA)
Immunofluorescence staining of A549 cells with PACO59920 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte development.
Synonyms:
Transmembrane protein 88, TMEM88, TMEM88A
UniProt Protein Function:
TMEM88: Belongs to the TMEM88 family.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 17p13.1Cellular Component: plasma membrane; integral to membraneBiological Process: Wnt receptor signaling pathway; multicellular organismal development
