The TMEM70 Polyclonal Antibody (CAB13712) is a valuable tool for researchers studying TMEM70, a transmembrane protein involved in mitochondrial ATP synthase biogenesis. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the TMEM70 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in mitochondrial biology and energy metabolism.TMEM70 is critical for proper function of ATP synthase, the enzyme responsible for generating ATP in mitochondria. Dysregulation of TMEM70 has been linked to mitochondrial diseases and energy metabolism disorders, highlighting its importance in cellular energy production.
Research on TMEM70 can provide insights into the molecular mechanisms underlying these diseases and may lead to the development of new therapeutic strategies targeting mitochondrial dysfunction.Overall, the TMEM70 Polyclonal Antibody is a valuable asset for researchers investigating mitochondrial biogenesis, energy metabolism, and mitochondrial diseases. Its specificity and sensitivity make it a reliable tool for studying TMEM70 function and dysfunction in various biological contexts.
Product Name:
TMEM70 Rabbit Polyclonal Antibody
SKU:
CAB13712
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 161-260 of human TMEM70 (NP_060336.3).
This gene likely encodes a mitochondrial membrane protein. The encoded protein may play a role in biogenesis of mitochondrial ATP synthase. Mutations in this gene have been associated with neonatal mitochondrial encephalocardiomyopathy due to ATP synthase deficiency. Alternatively spliced transcript variants have been described.
Purification Method:
Affinity purification
Gene ID:
54968
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HeLa cells, using TMEM70 Rabbit pAb (CAB13712) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
