TMEM59L Antibody (PACO30626)
- SKU:
- PACO30626
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
TMEM59L Antibody (PACO30626)
The TMEM59L Polyclonal Antibody (PAC030626) is a valuable tool for researchers studying TMEM59L, a transmembrane protein with roles in neuronal development and Alzheimer's disease. Raised in rabbits, this antibody shows high reactivity with human samples and has been validated for use in Western blotting applications. By binding specifically to the TMEM59L protein, researchers can accurately detect and analyze its expression in various cell types, making it an ideal choice for studies in neuroscience and neurodegenerative diseases.
TMEM59L, also known as WNK1 kinase-binding protein, has been implicated in regulating protein trafficking and synaptic function in the brain. Research into TMEM59L's function has suggested its involvement in Alzheimer's disease pathogenesis, making it a promising target for therapeutic interventions. By understanding the role of TMEM59L in neuronal health and disease, researchers may uncover new avenues for developing treatments for neurodegenerative disorders.
| Antibody Name: | TMEM59L Antibody (PACO30626) |
| Antibody SKU: | PACO30626 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Transmembrane protein 59-like protein (27-267AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: TMEM59L antibody at 3µg/ml + 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 38 kDa Observed band size: 38 kDa . |
 | Immunohistochemistry of paraffin-embedded human ovarian cancer using PACO30626 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO30626 at dilution of 1:100. |
| Background: | Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding. |
| Synonyms: | Transmembrane protein 59-like (Brain-specific membrane-anchored protein), TMEM59L, BSMAP C19orf4 |
| UniProt Protein Function: | TMEM59L: Modulates the O-glycosylation and complex N- glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding. Belongs to the TMEM59 family.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 19p12Cellular Component: Golgi membrane; membrane; integral to membrane |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a predicted type-I membrane glycoprotein. The encoded protein may play a role in functioning of the central nervous system. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UK28 |
| NCBI GenInfo Identifier: | 6912274 |
| NCBI Gene ID: | 25789 |
| NCBI Accession: | NP_036241 |
| UniProt Secondary Accession: | Q9UK28 |
| UniProt Related Accession: | Q9UK28 |
| Molecular Weight: | |
| NCBI Full Name: | transmembrane protein 59-like |
| NCBI Synonym Full Names: | transmembrane protein 59 like |
| NCBI Official Symbol: | TMEM59LÂ Â |
| NCBI Official Synonym Symbols: | BSMAP; C19orf4Â Â |
| NCBI Protein Information: | transmembrane protein 59-like |
| UniProt Protein Name: | Transmembrane protein 59-like |
| UniProt Synonym Protein Names: | Brain-specific membrane-anchored protein |
| Protein Family: | Transmembrane protein |
| UniProt Gene Name: | TMEM59LÂ Â |
| UniProt Entry Name: | TM59L_HUMAN |
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