The TMEM59 Polyclonal Antibody (CAB16089) is a powerful tool for researchers studying TMEM59, a transmembrane protein associated with Alzheimer's disease and other neurological conditions. This antibody, produced through immunization of rabbits, exhibits high specificity for human samples and is validated for use in Western blot applications. By binding to the TMEM59 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in neuroscience and neurodegenerative diseases.TMEM59, also known as Cell surface glycoprotein M6a, is involved in various cellular processes, including synaptic plasticity and lipid metabolism.
Dysregulation of TMEM59 has been linked to Alzheimer's disease and other neurological disorders, making it a promising target for therapeutic interventions. By deciphering the role of TMEM59 in these diseases, researchers can pave the way for the development of novel treatments that target this protein and its associated pathways. Overall, the TMEM59 Polyclonal Antibody (CAB16089) serves as a valuable tool for researchers seeking to unravel the complexities of TMEM59 and its implications in neurodegenerative diseases, laying the groundwork for potential breakthroughs in the field of neuroscience.
Product Name:
TMEM59 Rabbit Polyclonal Antibody
SKU:
CAB16089
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 36-230 of human TMEM59 (NP_004863.2).
Cell membrane, Golgi apparatus membrane, Late endosome membrane, Lysosome membrane, Single-pass type I membrane protein
Calculated MW:
36kDa
Observed MW:
37kDa
This gene encodes a protein shown to regulate autophagy in response to bacterial infection. This protein may also regulate the retention of amyloid precursor protein (APP) in the Golgi apparatus through its control of APP glycosylation. Overexpression of this protein has been found to promote apoptosis in a glioma cell line. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
9528
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TMEM59 Rabbit pAb (CAB16089) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
