TMEM43 Rabbit Polyclonal Antibody (CAB8509)
- SKU:
- CAB8509
- Product Type:
- Antibody
- Applications:
- WB
- IHC
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | TMEM43 Rabbit Polyclonal Antibody |
SKU: | CAB8509 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 80-310 of human TMEM43 (NP_077310.1). |
Sequence: | VAPE NEGR LVHI IGAL RTSK LLSD PNYG VHLP AVKL RRHV EMYQ WVET EESR EYTE DGQV KKET RYSY NTEW RSEI INSK NFDR EIGH KNPS AMAV ESFM ATAP FVQI GRFF LSSG LIDK VDNF KSLS LSKL EDPH VDII RRGD FFYH SENP KYPE VGDL RVSF SYAG LSGD DPDL GPAH VVTV IARQ RGDQ LVPF STKS GDTL LLLH HGDF SAEE VFHR ELRS NSMK TWG |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | LUMA; ARVC5; ARVD5; AUNA3; EDMD7; AUNA2; TMEM43 |
Positive Sample: | SKOV3,SW620,MCF7,Mouse kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum, Multi-pass membrane protein, Nucleus inner membrane. |
Calculated MW: | 45kDa |
Observed MW: | 45kDa |
This gene belongs to the TMEM43 family. Defects in this gene are the cause of familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5), also known as arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5). Arrhythmogenic right ventricular dysplasia is an inherited disorder, often involving both ventricles, and is characterized by ventricular tachycardia, heart failure, sudden cardiac death, and fibrofatty replacement of cardiomyocytes. This gene contains a response element for PPAR gamma (an adipogenic transcription factor), which may explain the fibrofatty replacement of the myocardium, a characteristic pathological finding in ARVC.
Purification Method: | Affinity purification |
Gene ID: | 79188 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |