The TMEM237 Polyclonal Antibody (PAC063167) is a valuable tool for researchers studying TMEM237, a transmembrane protein involved in ciliogenesis and ciliary function. This antibody, produced in rabbits, has high specificity for human samples and is suitable for use in Western blot applications. By binding to the TMEM237 protein, the antibody allows for precise detection and analysis in various cell types, making it ideal for investigations in cell biology and cilia-related research.TMEM237 is a key player in the formation and maintenance of cilia, specialized organelles with crucial roles in cellular signaling and sensory functions.
Dysfunctions in cilia have been associated with a wide range of human diseases, including ciliopathies and developmental disorders. By studying TMEM237, researchers can gain insights into the mechanisms underlying ciliary biology and potential therapeutic targets for cilia-related disorders.This TMEM237 Polyclonal Antibody is a powerful tool for exploring the functions of TMEM237 and its implications in ciliogenesis, providing valuable information for advancing our understanding of ciliary biology and its relevance to human health.
Antibody Name:
TMEM237 Antibody (PACO63167)
Antibody SKU:
PACO63167
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:1000-1:5000
Species Reactivity:
Human
Immunogen:
Peptide sequence from Human Transmembrane protein 237 protein (59-78AA)
Western Blot. Positive WB detected in: Hela whole cell lysate, PC-3 whole cell lysate, MCF-7 whole cell lysate. All lanes: TMEM237 antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 46, 45, 49, 36, 47 kDa. Observed band size: 46 kDa.
Background:
Component of the transition zone in primary cilia. Required for ciliogenesis.
Synonyms:
Transmembrane protein 237 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein), TMEM237, ALS2CR4
UniProt Protein Function:
ALS2CR4: Component of the transition zone in primary cilia. Required for ciliogenesis. Defects in TMEM237 are the cause of Joubert syndrome type 14 (JBTS14). An autosomal recessive disorder characterized by severe mental retardation, hypotonia, breathing abnormalities in infancy, and dysmorphic facial features. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable JBTS14 features include renal disease, abnormal eye movements, and postaxial polydactyly. Belongs to the TMEM237 family. 5 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 2q33.2Cellular Component: membrane; integral to membraneBiological Process: regulation of Wnt receptor signaling pathway; cilium biogenesisDisease: Joubert Syndrome 1; Joubert Syndrome 14
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a tetraspanin protein that is thought to be involved in WNT signaling. Defects in this gene are a cause of Joubert syndrome-14. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
