The TMEM237 Polyclonal Antibody (PACO22144) is a vital tool for researchers studying TMEM237, a transmembrane protein associated with ciliogenesis and cilia-related disorders. This antibody, produced in rabbits, has high specificity for human samples and has been validated for use in various applications, including Western blotting. By targeting the TMEM237 protein, this antibody allows for precise detection and analysis in different cell types, making it perfect for investigations in the fields of cell biology and genetics.TMEM237 is a crucial player in the formation and function of primary cilia, cellular appendages involved in signaling pathways and sensory processes.
Mutations in TMEM237 have been linked to ciliopathy disorders, underscoring its importance in human health and development. Research on TMEM237 holds promise for understanding cilia-related diseases and advancing potential therapeutic interventions targeting these conditions. The TMEM237 Polyclonal Antibody provides researchers with a valuable tool to further explore the functions and implications of TMEM237 in various biological contexts.
Antibody Name:
TMEM237 Antibody (PACO22144)
Antibody SKU:
PACO22144
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from internal of human ALS2CR4.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from Jurkat cells, using ALS2CR4 antibody.
Background:
Component of the transition zone in primary cilia. Required for ciliogenesis.
Synonyms:
AL2S4; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4;
UniProt Protein Function:
ALS2CR4: Component of the transition zone in primary cilia. Required for ciliogenesis. Defects in TMEM237 are the cause of Joubert syndrome type 14 (JBTS14). An autosomal recessive disorder characterized by severe mental retardation, hypotonia, breathing abnormalities in infancy, and dysmorphic facial features. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable JBTS14 features include renal disease, abnormal eye movements, and postaxial polydactyly. Belongs to the TMEM237 family. 5 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 2q33.2Cellular Component: membrane; integral to membraneBiological Process: regulation of Wnt receptor signaling pathway; cilium biogenesisDisease: Joubert Syndrome 1; Joubert Syndrome 14
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a tetraspanin protein that is thought to be involved in WNT signaling. Defects in this gene are a cause of Joubert syndrome-14. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
