TMEM2 Rabbit Polyclonal Antibody (CAB18439)
- SKU:
- CAB18439
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | TMEM2 Rabbit Polyclonal Antibody |
SKU: | CAB18439 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1150-1250 of human TMEM2 (NP_037522.1). |
Sequence: | ERVK IQAA TDSK DISN CMAK AYPQ YYRK PSVV KRMP AMLT GLCQ GCGT RQVV FTSD PHKS YLPV QFQS PDKA ETQR GDPS VISV NGTD FTFR SAGV LLLV V |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | TMEM2 |
Positive Sample: | Mouse lung |
Cellular Localization: | cytosol, extracellular exosome, nucleolus, plasma membrane |
Calculated MW: | 154kDa |
Observed MW: | 200kDa |
This gene encodes a type II transmembrane protein that belongs to the interferon-induced transmembrane (IFITM) protein superfamily. The encoded protein functions as a cell surface hyaluronidase that cleaves extracellular high molecular weight hyaluronan into intermediate size fragments before internalization and degradation in the lysosome. It also has an interferon-mediated antiviral function in humans through activation of the JAK STAT signaling pathway. The activation of this gene by transcription factor SOX4 in breast cancer cells has been shown to mediate the pathological effects of SOX4 on cancer progression. Naturally occurring mutations in this gene are associated with autosomal recessive non-syndromic hearing loss.
Purification Method: | Affinity purification |
Gene ID: | 23670 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |