null

STING/TMEM173 Rabbit Polyclonal Antibody (CAB3575)

SKU:
CAB3575
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Autophagy
  • Autophagy Antibodies Anti-STING / TMEM173 Antibody CAB3575
  • Autophagy Antibodies Anti-STING / TMEM173 Antibody CAB3575
  • Autophagy Antibodies Anti-STING / TMEM173 Antibody CAB3575
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:STING/TMEM173 Rabbit Polyclonal Antibody
SKU:CAB3575
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 139-379 of human STING/TMEM173 (NP_938023.1).
Sequence:LAPA EISA VCEK GNFN VAHG LAWS YYIG YLRL ILPE LQAR IRTY NQHY NNLL RGAV SQRL YILL PLDC GVPD NLSM ADPN IRFL DKLP QQTG DHAG IKDR VYSN SIYE LLEN GQRA GTCV LEYA TPLQ TLFA MSQY SQAG FSRE DRLE QAKL FCRT LEDI LADA PESQ NNCR LIAY QEPA DDSS FSLS QEVL RHLR QEEK EEVT VGSL KTSA VPST STMS QEPE LLIS GMEK PLPL RTDF S
Tested Applications:WB IHC-P IF/ICC IP ELISA
Recommended Dilution:WB,1:100 - 1:500 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:ERIS; MITA; MPYS; SAVI; NET23; STING; hMITA; hSTING; TMEM173; STING-beta; STING/TMEM173
Positive Sample:THP-1,Mouse spleen,Mouse thymus,Rat thymus,Rat lung
Conjugate:Unconjugated
Cellular Localization:Cell membrane, Cytoplasm, Endoplasmic reticulum membrane, Mitochondrion outer membrane, Multi-pass membrane protein, perinuclear region.
Calculated MW:42kDa
Observed MW:40kDa

This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants.

Purification Method:Affinity purification
Gene ID:340061
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates, using STING/TMEM173 Rabbit pAb (CAB3575) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.

Related Products