The TMEM165 Polyclonal Antibody (CAB17183) is a powerful tool for researchers studying TMEM165, a transmembrane protein involved in calcium homeostasis and membrane trafficking processes. This rabbit-derived antibody is highly specific for human samples and has been validated for use in Western blot and immunohistochemistry applications.TMEM165 plays a crucial role in maintaining calcium levels within cells and ensuring proper function of various organelles involved in cellular transport and signaling. Dysregulation of TMEM165 has been linked to diseases such as osteogenesis imperfecta and neurodegenerative disorders, making it an important target for research in the fields of cell biology and genetics.
By using the TMEM165 Polyclonal Antibody, researchers can detect and analyze the expression of TMEM165 in different cell types and tissues, helping to uncover its precise role in cellular physiology and disease pathology. This antibody is a valuable tool for advancing our understanding of TMEM165 function and developing potential therapeutic strategies for related disorders.
Product Name:
TMEM165 Rabbit Polyclonal Antibody
SKU:
CAB17183
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 172-230 of human TMEM165 (NP_060945.2).
This gene encodes a predicted transmembrane protein with a perinuclear Golgi-like distribution in fibroblasts. Mutations in this gene are associated with the autosomal recessive disorder congenital disorder of glycosylation, type IIk. Knockdown of this gene's expression causes decreased sialylation in HEK cells and suggests this gene plays a role in terminal Golgi glycosylation. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
55858
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HeLa cells, using TMEM165 Rabbit pAb (CAB17183) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 5min.
