The TMED10 Polyclonal Antibody (CAB10006) is a valuable tool for researchers studying TMED10, a protein involved in intracellular protein trafficking and sorting. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. It binds to the TMED10 protein, allowing for accurate detection and analysis in various cell types, making it ideal for investigations in cell biology and molecular research.TMED10 plays a crucial role in the sorting and delivery of proteins within cells, contributing to the proper functioning of organelles such as the Golgi apparatus and endoplasmic reticulum.
Dysfunction of TMED10 has been implicated in various diseases, including neurodegenerative disorders and cancer. By understanding the mechanisms of TMED10, researchers can potentially uncover new therapeutic targets for these conditions and improve our knowledge of intracellular protein trafficking pathways.The TMED10 Polyclonal Antibody is a reliable tool for studying the function and localization of TMED10 in cellular processes, offering valuable insights into its role in health and disease.
Product Name:
TMED10 Polyclonal Antibody
SKU:
CAB21344
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 35-190 of human TMED10 (NP_006818.3).
This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8.
Purification Method:
Affinity purification
Gene ID:
10972
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using TMED10 Rabbit pAb (CAB21344) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
