The TMED10 Polyclonal Antibody (CAB18090) is a valuable tool for researchers studying TMED10, a protein involved in intracellular trafficking and vesicle transport. This rabbit-derived antibody is highly specific for human samples and has been validated for use in Western blot applications. By binding to the TMED10 protein, this antibody enables the detection and analysis of TMED10 in various cell types, making it ideal for investigations in cell biology and membrane trafficking.TMED10, also known as p24 family protein, plays a crucial role in the transport of proteins and lipids within cells, contributing to cellular homeostasis and organelle function.
Its importance in intracellular trafficking processes makes it a key target for research into diseases such as neurodegenerative disorders, metabolic conditions, and infectious diseases. Understanding the function of TMED10 can provide insights into cellular communication and signaling pathways, leading to the development of novel therapeutic strategies for treating related disorders.
Product Name:
[KO Validated] TMED10 Rabbit Polyclonal Antibody
SKU:
CAB18090
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 35-190 of human TMED10 (NP_006818.3).
This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8.
Purification Method:
Affinity purification
Gene ID:
10972
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and TMED10 knockout (KO) 293T cells, using [KO Validated] TMED10 Rabbit pAb (CAB18090) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
