The TMCO1 Polyclonal Antibody (PAC051178) is a valuable tool for researchers studying the transmembrane and coiled-coil domain-containing protein 1 (TMCO1). This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for Western blot applications. By binding specifically to the TMCO1 protein, this antibody enables accurate detection and analysis in a variety of cell types.TMCO1 is a protein involved in cellular processes related to transmembrane transport and protein folding. Research suggests that TMCO1 may play a role in diseases such as glaucoma and non-syndromic hearing impairment.
By investigating the function of TMCO1 using this antibody, researchers can gain insight into its role in these conditions and potentially identify new therapeutic targets.The TMCO1 Polyclonal Antibody is a valuable tool for studies in molecular biology and genetics, providing researchers with a reliable means of detecting and analyzing TMCO1 expression. Its high specificity and sensitivity make it an ideal choice for projects investigating the function and significance of TMCO1 in health and disease.
IHC image of PACO51178 diluted at 1:500 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system..
Immunofluorescent analysis of HepG2 cells using PACO51178 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
IHC image of PACO51178 diluted at 1:500 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store
Synonyms:
Calcium load-activated calcium channel (CLAC channel) (Transmembrane and coiled-coil domain-containing protein 1) (Transmembrane and coiled-coil domains protein 4) (Xenogeneic cross-immune protein PCIA3), TMCO1, TMCC4
