The TMC2 Polyclonal Antibody (PAC046998) is a valuable tool for researchers studying the TMC2 protein, an essential component of the mechanotransduction machinery in hair cells of the inner ear. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in various applications including Western blot and immunofluorescence.TMC2 is a critical player in the conversion of mechanical stimuli into electrical signals in sensory cells, making it a key target for investigating hearing loss and auditory dysfunction. By targeting the TMC2 protein, researchers can gain insights into the mechanisms underlying hearing impairment and potentially identify new therapeutic targets for addressing hearing disorders.
The versatility of the TMC2 Polyclonal Antibody makes it an indispensable tool for scientists working in the fields of auditory neuroscience, sensory biology, and otolaryngology. Its ability to specifically detect TMC2 protein expression in various cell types and tissues opens up avenues for exploring the intricate workings of the auditory system and developing innovative interventions for hearing-related conditions.
Antibody Name:
TMC2 Antibody (PACO46998)
Antibody SKU:
PACO46998
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Transmembrane channel-like protein 2 protein (6-206AA)
Immunofluorescent analysis of Hela cells using PACO46998 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Probable ion channel required for the normal function of cochlear hair cells.
Synonyms:
Transmembrane channel-like protein 2 (Transmembrane cochlear-expressed protein 2), TMC2, C20orf145
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
This gene encodes a transmembrane protein that is necesssary for mechanotransduction in cochlear hair cells of the inner ear. Mutations in this gene may underlie hereditary disorders of balance and hearing. [provided by RefSeq, Aug 2015]
