The TM7SF3 Antibody (PAC01278) is a polyclonal antibody designed for research involving TM7SF3, a protein playing a crucial role in cholesterol homeostasis and lipid metabolism. This antibody, raised in rabbits, is highly specific to human samples and is validated for use in various applications such as Western blot and immunohistochemistry.TM7SF3, also known as 3 beta-hydroxysterol delta-14 reductase, is a key enzyme involved in the biosynthesis of cholesterol. Dysregulation of cholesterol metabolism has been linked to various diseases including atherosclerosis, metabolic disorders, and certain types of cancer.
By targeting TM7SF3, researchers can gain insights into the mechanisms underlying these diseases and potentially identify novel therapeutic targets.Furthermore, the TM7SF3 Antibody offers researchers a powerful tool for studying lipid metabolism and cholesterol regulation in both normal and diseased tissues. Its high specificity and sensitivity make it an ideal choice for investigating the role of TM7SF3 in various cellular processes, making it a valuable asset for studies in lipid biology and metabolic disorders.
Involved in the inhibition of cytokine-induced death of pancreatic beta cells. Involved in the promotion of insulin secretion from pancreatic beta cells (PubMed:21853325). Is a downstream transcriptional target of p53/TP53, and acts as a pro-survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR) (PubMed:27740623).
