The TM4SF1 Polyclonal Antibody (PAC020647) is a valuable tool for studying TM4SF1, a transmembrane protein associated with cell adhesion and migration processes. This antibody, raised in rabbits, is specifically designed for use in research involving TM4SF1 in various cell types. Validated for Western blot applications, it allows for the detection and analysis of TM4SF1 protein expression levels.TM4SF1, also known as transmembrane 4 L six family member 1, is involved in cell signaling pathways that regulate cellular processes such as proliferation, migration, and invasion.
Its role in promoting tumor progression and metastasis makes it a target of interest in cancer research. Understanding the function of TM4SF1 is essential for developing targeted therapies aimed at inhibiting its activity in cancer cells.Overall, the TM4SF1 Polyclonal Antibody is a valuable tool for researchers studying the role of TM4SF1 in cancer biology and other cellular processes. Its high reactivity with human samples and specificity for TM4SF1 protein make it an ideal choice for studies in cell biology and cancer research.
Antibody Name:
TM4SF1 Antibody (PACO20647)
Antibody SKU:
PACO20647
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human TM4SF1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20647(TM4SF1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20647(TM4SF1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas.
Synonyms:
transmembrane 4 L six family member 1
UniProt Protein Function:
TM4SF1: a multi-pass membrane protein. Member of the transmembrane 4 superfamily, also known as the tetraspanin family. These proteins apparently mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This protein is highly expressed in lung, breast, colon and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular. Present in high molecular weight complexes in tumor cells.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 3q21-q25Cellular Component: integral to plasma membrane
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008]
