The TLR8 Polyclonal Antibody (CAB1489) is a valuable tool for researchers studying Toll-like receptor 8 (TLR8), a key player in the innate immune response to viral and bacterial infections. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to TLR8 protein, this antibody allows for precise detection and analysis of TLR8 expression in various cell types, making it essential for research in immunology and infectious diseases.TLR8 is known for its role in recognizing single-stranded RNA from viruses and activating the immune response to combat infections.
Understanding the function and regulation of TLR8 is crucial for developing new therapeutic strategies to enhance immune defense against pathogens. Research on TLR8 can also lead to insights into autoimmune diseases and chronic inflammatory conditions where TLR8 signaling may be dysregulated. The TLR8 Polyclonal Antibody (CAB1489) provides researchers with a reliable tool to investigate the role of TLR8 in these contexts and advance our understanding of immune responses in health and disease.
Product Name:
TLR8 Rabbit Polyclonal Antibody
SKU:
CAB1489
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 849-1041 of human TLR8 (NP_619542.1).
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.
Purification Method:
Affinity purification
Gene ID:
51311
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HepG2 cells, using TLR8 Rabbit pAb (CAB1489) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
