The TLR7 Rabbit Monoclonal Antibody (CAB19126) is a valuable tool for researchers studying Toll-like receptor 7 (TLR7), a key player in the innate immune response to viral infections. This antibody, produced in rabbits, has high specificity and sensitivity for TLR7 in human samples, making it an ideal choice for Western blot applications.TLR7 is a pattern recognition receptor that plays a crucial role in recognizing single-stranded RNA viruses and triggering antiviral immune responses. By targeting TLR7 with this monoclonal antibody, researchers can investigate the signaling pathways and immune responses activated by TLR7 in different cell types and conditions.
Studies have shown that dysregulation of TLR7 signaling can lead to chronic inflammation, autoimmune diseases, and viral infections. This makes TLR7 a promising target for therapeutic interventions in conditions such as lupus, arthritis, and viral hepatitis. Understanding the mechanisms of TLR7 activation and regulation is essential for developing new treatments and vaccines.Overall, the TLR7 Rabbit Monoclonal Antibody (CAB19126) provides researchers with a reliable tool to explore the role of TLR7 in immune responses and disease development, ultimately contributing to the advancement of immunology and infectious disease research.
Product Name:
TLR7 Rabbit Monoclonal Antibody
SKU:
CAB19126
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 950-1049 of human TLR7 (Q9NYK1).
Cytoplasmic vesicle, Endoplasmic reticulum membrane, Endosome, Lysosome, Single-pass type I membrane protein, phagosome.
Calculated MW:
121kDa
Observed MW:
140kDa
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The human TLR family comprises 11 members. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. For the recognition of structural components in foreign microorganisms, the various TLRs exhibit different patterns of expression as well; in this way for example, TLR-3, -7, and -8 are essential in the recognition of single-stranded RNA viruses. TLR7 senses single-stranded RNA oligonucleotides containing guanosine- and uridine-rich sequences from RNA viruses, a recognition occuring in the endosomes of plasmacytoid dendritic cells and B cells. This gene is predominantly expressed in lung, placenta, and spleen, and is phylogenetically related and lies in close proximity to another family member, TLR8, on chromosome X.
Purification Method:
Affinity purification
Gene ID:
51284
Clone Number:
ARC0401
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of Raji cells, using TLR7 antibody (CAB19126) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
