Tlr7 Antibody (PACO30430)
- SKU:
- PACO30430
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Tlr7 Antibody (PACO30430)
The TLR7 Antibody (PAC030430) is a specialized tool for researchers studying Toll-like receptor 7 (TLR7), a key player in the innate immune system's response to viral infections. This highly specific antibody is produced using cutting-edge technology and is validated for use in a variety of applications, including Western blot and immunohistochemistry.TLR7 is a crucial component of the immune system that recognizes viral RNA and triggers a signaling cascade that leads to the production of pro-inflammatory cytokines. Dysregulation of TLR7 signaling has been implicated in various diseases, including autoimmune disorders and viral infections.
By targeting TLR7 with this antibody, researchers can gain insights into its function and potential as a therapeutic target.Whether investigating the role of TLR7 in antiviral immunity or exploring its potential as a target for drug development, the TLR7 Antibody (PAC030430) offers researchers a high-quality tool for their immunology and infectious disease studies. Order now to advance your research in this critical area of study.
| Antibody Name: | Tlr7 Antibody (PACO30430) |
| Antibody SKU: | PACO30430 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000 |
| Species Reactivity: | Mouse, Human |
| Immunogen: | Recombinant Mouse Toll-like receptor 7 protein (27-348AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot Positive WB detected in: Jurkat whole cell lysate, K562 whole cell lysate, A549 whole cell lysate All lanes: Tlr7 antibody at 2µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 122 kDa Observed band size: 122 kDa . |
| Background: | Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response |
| Synonyms: | Toll-like receptor 7, Tlr7 |
| UniProt Protein Function: | TLR7: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1. Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells. Belongs to the Toll-like receptor family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Cellular Component: cytoplasm; cytoplasmic vesicle; endoplasmic reticulum; endosome; integral to membrane; lysosome; membrane; plasma membrane; receptor complex Molecular Function:double-stranded RNA binding; drug binding; protein binding; single-stranded RNA binding; siRNA binding; transmembrane receptor activity Biological Process: defense response to virus; I-kappaB phosphorylation; immune response; immune system process; inflammatory response; innate immune response; microglial cell activation; MyD88-dependent toll-like receptor signaling pathway; positive regulation of chemokine production; positive regulation of interferon-alpha biosynthetic process; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-gamma biosynthetic process; positive regulation of interleukin-6 production; positive regulation of interleukin-8 biosynthetic process; positive regulation of interleukin-8 production; positive regulation of NF-kappaB import into nucleus; regulation of protein amino acid phosphorylation; signal transduction; toll-like receptor 7 signaling pathway; toll-like receptor signaling pathway |
| UniProt Code: | P58681 |
| NCBI GenInfo Identifier: | 595582289 |
| NCBI Gene ID: | 170743 |
| NCBI Accession: | NP_001277684.1 |
| UniProt Secondary Accession: | P58681,Q923I1, |
| UniProt Related Accession: | P58681 |
| Molecular Weight: | 40.8 kDa |
| NCBI Full Name: | toll-like receptor 7 isoform a |
| NCBI Synonym Full Names: | toll-like receptor 7 |
| NCBI Official Symbol: | Tlr7Â Â |
| NCBI Protein Information: | toll-like receptor 7 |
| UniProt Protein Name: | Toll-like receptor 7 |
| Protein Family: | Toll-like receptor |
| UniProt Gene Name: | Tlr7Â Â |
| UniProt Entry Name: | TLR7_MOUSE |
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