The TLR6 Polyclonal Antibody (CAB8185) is a valuable tool for researchers studying Toll-like receptor 6 (TLR6), a member of the Toll-like receptor family known for its role in recognizing bacterial lipopeptides and triggering immune responses. This antibody, generated in rabbits, is highly specific for human TLR6 and has been validated for use in Western blotting applications.TLR6 is important for host defense against bacterial infections and plays a key role in activating the innate immune system. By targeting TLR6 with this antibody, researchers can investigate the function and regulation of TLR6 in various cell types, providing insights into the mechanisms of immune response and potential therapeutic targets for infectious diseases.
With its high reactivity and specificity, the TLR6 Polyclonal Antibody is an essential tool for studying the role of TLR6 in immune signaling pathways and infection immunity. Its use in research on bacterial recognition and immune response modulation makes it a valuable asset for studies in immunology, microbiology, and infectious disease research.
Product Name:
TLR6 Rabbit Polyclonal Antibody
SKU:
CAB8185
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 697-796 of human TLR6 (NP_006059.2).
Cell membrane, Cytoplasmic vesicle, Single-pass type I membrane protein, phagosome membrane.
Calculated MW:
92kDa
Observed MW:
100kDa
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.
Purification Method:
Affinity purification
Gene ID:
10333
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TLR6 antibody (CAB8185) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
