The TLR5 Rabbit Monoclonal Antibody (CAB8765) is a powerful tool for research into Toll-like receptor 5, a key player in the immune response to bacterial flagellin. This antibody, generated in rabbits, exhibits high specificity and sensitivity when detecting TLR5 in various samples, particularly human tissues. Validated for use in Western blot applications, it effectively binds to the TLR5 protein, enabling precise detection and analysis in a variety of cell types.TLR5 is a crucial component of the innate immune system, recognizing and responding to bacterial pathogens through the activation of inflammatory pathways. Studies have shown that dysregulation of TLR5 can contribute to the development of inflammatory diseases and even cancer.
By targeting TLR5 with this monoclonal antibody, researchers can gain valuable insights into its function and explore potential therapeutic interventions for conditions related to immune dysregulation.Overall, the TLR5 Rabbit Monoclonal Antibody (CAB8765) offers a robust tool for investigating the role of TLR5 in immunity, inflammation, and disease pathogenesis. Its reliability and specificity make it well-suited for research in immunology, cancer biology, and infectious diseases, providing valuable data that could lead to the development of novel treatment strategies.
Product Name:
TLR5 Rabbit Monoclonal Antibody
SKU:
CAB8765
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 258-404 of human TLR5 (O60602).
This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.
Purification Method:
Affinity purification
Gene ID:
7100
Clone Number:
ARC1294
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TLR5 Rabbit mAb (CAB8765) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
