The TLR5 Polyclonal Antibody (CAB1721) is a powerful tool for researchers studying Toll-like receptor 5 (TLR5), a key protein involved in the innate immune response to bacterial flagellin. This antibody, produced in rabbits, has been extensively validated for use in Western blot applications and exhibits high reactivity with human samples.TLR5 is a pattern recognition receptor that plays a crucial role in detecting bacterial pathogens and initiating immune responses. By binding specifically to TLR5, this antibody enables precise detection and analysis of TLR5 expression in a variety of cell types, making it an invaluable asset for investigations in immunology, infectious diseases, and inflammation research.
The intricate interplay between TLR5 and the immune system makes it a potential target for therapeutic interventions in diseases such as infectious illnesses, inflammatory disorders, and cancer. Harnessing the power of the TLR5 Polyclonal Antibody can aid in unraveling the complexities of TLR5 signaling pathways, paving the way for the development of novel treatments and interventions.
Product Name:
TLR5 Rabbit Polyclonal Antibody
SKU:
CAB1721
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 714-858 of human TLR5 (NP_003259.2).
This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.
Purification Method:
Affinity purification
Gene ID:
7100
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from HeLa cells, using TLR5 Rabbit pAb (CAB1721).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
