TLR3 Rabbit Polyclonal Antibody (CAB11778)
- SKU:
- CAB11778
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | TLR3 Rabbit Polyclonal Antibody |
SKU: | CAB11778 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 500-700 of human TLR3 (NP_003256.1). |
Sequence: | SPFQ PLRN LTIL DLSN NNIA NIND DMLE GLEK LEIL DLQH NNLA RLWK HANP GGPI YFLK GLSH LHIL NLES NGFD EIPV EVFK DLFE LKII DLGL NNLN TLPA SVFN NQVS LKSL NLQK NLIT SVEK KVFG PAFR NLTE LDMR FNPF DCTC ESIA WFVN WINE THTN IPEL SSHY LCNT PPHY HGFP VRLF DTSS CKDS A |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | CD283; IIAE2; IMD83; TLR3 |
Positive Sample: | HeLa,Rat liver,Mouse lung |
Conjugate: | Unconjugated |
Cellular Localization: | Early endosome, Endoplasmic reticulum membrane, Endosome membrane, Single-pass type I membrane protein. |
Calculated MW: | 104kDa |
Observed MW: | 104kDa |
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It thus plays a role in host defense against multiple viruses.
Purification Method: | Affinity purification |
Gene ID: | 7098 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |