TLR2 Rabbit Monoclonal Antibody (CAB19125)
- SKU:
- CAB19125
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
Product Name: | TLR2 Rabbit Monoclonal Antibody |
SKU: | CAB19125 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-784 of human TLR2 (NP_003255.2). |
Sequence: | MPHT LWMV WVLG VIIS LSKE ESSN QASL SCDR NGIC KGSS GSLN SIPS GLTE AVKS LDLS NNRI TYIS NSDL QRCV NLQA LVLT SNGI NTIE EDSF SSLG SLEH LDLS YNYL SNLS SSWF KPLS SLTF LNLL GNPY KTLG ETSL FSHL TKLQ ILRV GNMD TFTK IQRK DFAG LTFL EELE IDAS DLQS YEPK SLKS IQNV SHLI LHMK QHIL LLEI FVDV TSSV ECLE LRDT DLDT FHFS ELST GETN SLIK KFTF RNVK ITDE SLFQ VMKL LNQI SGLL ELEF DDCT LNGV GNFR ASDN DRVI DPGK VETL TIRR LHIP RFYL FYDL STLY SLTE RVKR ITVE NSKV FLVP CLLS QHLK SLEY LDLS ENLM VEEY LKNS ACED AWPS LQTL ILRQ NHLA SLEK TGET LLTL KNLT NIDI SKNS FHSM PETC QWPE KMKY LNLS STRI HSVT GCIP KTLE ILDV SNNN LNLF SLNL PQLK ELYI SRNK LMTL PDAS LLPM LLVL KISR NAIT TFSK EQLD SFHT LKTL EAGG NNFI CSCE FLSF TQEQ QALA KVLI DWPA NYLC DSPS HVRG QQVQ DVRL SVSE CHRT ALVS GMCC ALFL LILL TGVL CHRF HGLW YMKM MWAW LQAK RKPR KAPS RNIC YDAF VSYS ERDA YWVE NLMV QELE NFNP PFKL CLHK RDFI PGKW IIDN IIDS IEKS HKTV FVLS ENFV KSEW CKYE LDFS HFRL FDEN NDAA ILIL LEPI EKKA IPQR FCKL RKIM NTKT YLEW PMDE AQRE GFWV NLRA AIKS |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | TIL4; CD282; TLR2 |
Positive Sample: | U-937 |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Single-pass type I membrane protein. |
Calculated MW: | 90kDa |
Observed MW: | 100kDa |
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 7097 |
Clone Number: | ARC0433 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |