The TLR13 Polyclonal Antibody (PACO03217) is a valuable tool for researchers studying Toll-like Receptor 13, a key player in the innate immune response. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot assays. By targeting TLR13, researchers can accurately detect and analyze this important receptor in various cell types, making it an ideal tool for investigations in immunology and infectious disease research.TLR13 is a crucial component of the immune system, recognizing bacterial RNA and activating the immune response to combat pathogens.
Its role in detecting and responding to microbial invaders highlights its importance in understanding host-pathogen interactions and developing novel strategies for combating infectious diseases. By studying TLR13 activity, researchers can gain insights into the mechanisms of immune defense and potentially identify new therapeutic targets for immune-related disorders.
Antibody Name:
TLR13 Antibody
Antibody SKU:
PACO03217
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:200-1:500
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Recombinant Protein
Form:
Liquid
Storage Buffer:
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Purification Method:
Affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
Toll-like receptor 13
UniProt Protein Function:
TLR13: Component of innate and adaptive immunity that recognizes and binds 23S rRNA from bacteria. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Specifically binds the 5'-CGGAAAGACC-3' sequence on bacterial 23S rRNA, a sequence also bound by MLS group antibiotics (including erythromycin). May also recognize vesicular stomatitis virus; however, these data require additional evidences. Belongs to the Toll-like receptor family.Protein type: Membrane protein, integral; Receptor, misc.Cellular Component: cytoplasm; endosome; integral to membrane; membraneMolecular Function: double-stranded RNA binding; protein binding; protein homodimerization activity; RNA binding; rRNA bindingBiological Process: immune system process; inflammatory response; innate immune response; MyD88-dependent toll-like receptor signaling pathway; regulation of MAPKKK cascade; response to virus; signal transduction; toll-like receptor 13 signaling pathway
