The TLR1 Polyclonal Antibody (CAB0997) is a valuable tool for research involving Toll-like receptor 1 (TLR1), a crucial component of the innate immune system responsible for recognizing bacterial lipoproteins. This antibody, generated in rabbits, specifically targets TLR1 in human samples and is validated for use in Western blot applications.TLR1 is a key player in the early detection of bacterial infections and activation of the immune response. By targeting TLR1 with this polyclonal antibody, researchers can further investigate its role in immune signaling pathways and its potential as a therapeutic target for infectious diseases.
The TLR1 Polyclonal Antibody enables precise detection and analysis of TLR1 protein levels in various cell types, making it an essential tool for studies in immunology, infectious diseases, and vaccine development. Understanding the function and regulation of TLR1 is crucial for advancing our knowledge of the immune response to bacterial pathogens and developing novel strategies for treatment and prevention.
Product Name:
TLR1 Rabbit Polyclonal Antibody
SKU:
CAB0997
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-290 of human TLR1 (NP_003254.2).
Cell membrane, Cytoplasmic vesicle, Single-pass type I membrane protein, phagosome membrane.
Calculated MW:
90kDa
Observed MW:
90kDa
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene.
Purification Method:
Affinity purification
Gene ID:
7096
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using TLR1 Rabbit pAb (CAB0997) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
