The TLL1 Polyclonal Antibody (PAC047718) is a valuable tool for researchers studying the TLL1 protein, an enzyme involved in extracellular matrix remodeling and tissue homeostasis. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting applications. By specifically binding to the TLL1 protein, this antibody enables accurate detection and analysis in various cell types, making it an essential tool for studies in molecular biology and tissue remodeling research.TLL1, also known as tolloid-like protein 1, is a member of the astacin metalloproteinase family and plays a crucial role in processes such as collagen degradation and cell migration.
Its involvement in extracellular matrix regulation makes TLL1 a key player in tissue remodeling during development and disease progression. By understanding the function and regulation of TLL1, researchers can uncover insights into conditions such as fibrosis, cancer metastasis, and wound healing, paving the way for potential therapeutic interventions targeting this enzyme.
Immunohistochemistry of paraffin-embedded human prostate cancer using PACO47718 at dilution of 1:100.
Immunofluorescent analysis of Hela cells using PACO47718 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human testis tissue using PACO47718 at dilution of 1:100.
Background:
Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.
Synonyms:
Tolloid-like protein 1 (EC 3.4.24), TLL1, TLL
UniProt Protein Function:
TLL1: Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis. Defects in TLL1 are the cause of atrial septal defect type 6 (ASD6). A congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. Belongs to the peptidase M12A family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted; EC 3.4.24.-; Secreted, signal peptide; ProteaseChromosomal Location of Human Ortholog: 4q32-q33Cellular Component: extracellular regionMolecular Function: metalloendopeptidase activity; serine-type endopeptidase activityBiological Process: extracellular matrix disassembly; skeletal developmentDisease: Atrial Septal Defect 6
UniProt Protein Details:
NCBI Summary:
This gene encodes an astacin-like, zinc-dependent, metalloprotease that belongs to the peptidase M12A family. This protease processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Studies in mice suggest that this gene plays multiple roles in the development of mammalian heart, and is essential for the formation of the interventricular septum. Allelic variants of this gene are associated with atrial septal defect type 6. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
