The TLK1 Polyclonal Antibody (CAB21987) is a valuable tool for researchers studying the TLK1 protein, a key regulator of cell cycle progression and DNA damage response. The antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications. By targeting the TLK1 protein, this antibody enables precise detection and analysis in various cell types, making it an excellent choice for studies in molecular biology and cancer research.TLK1, also known as Tousled-like kinase 1, plays a crucial role in maintaining genomic stability and proper cell division.
Dysregulation of TLK1 has been linked to a variety of diseases, including cancer and developmental disorders. By understanding the function of TLK1, researchers can unravel its role in disease development and potentially identify new therapeutic targets for intervention. The TLK1 Polyclonal Antibody is a valuable tool for unlocking the mysteries of TLK1 biology and its implications in human health.
Product Name:
TLK1 Polyclonal Antibody
SKU:
CAB21987
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human TLK1 (NP_036422.3).
The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
9874
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TLK1 antibody (CAB21987) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
